Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077834" target="_blank" >RIV/00209805:_____/17:00077834 - isvavai.cz</a>

Výsledek na webu

<a href="http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=28223430" target="_blank" >http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=28223430</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-16-0762-T" target="_blank" >10.1158/1055-9965.EPI-16-0762-T</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Popis výsledku v původním jazyce

Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI. Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls. Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P 1/4 0.007]. We observed significant heterogeneity by study design (P 1/4 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend1/4 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m2; OR, 1.2; 95%CI, 1.1-1.3; P1/4 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction &lt;0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-&lt;30 kg/m2) or obese (30þ kg/m2) in both younger and usual adulthood (vs. individuals consistently &lt;25 kg/m2), but not for those overweight or obese at only one time period. Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood. Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention.

Název v anglickém jazyce

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Popis výsledku anglicky

Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI. Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls. Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P 1/4 0.007]. We observed significant heterogeneity by study design (P 1/4 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend1/4 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m2; OR, 1.2; 95%CI, 1.1-1.3; P1/4 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction &lt;0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-&lt;30 kg/m2) or obese (30þ kg/m2) in both younger and usual adulthood (vs. individuals consistently &lt;25 kg/m2), but not for those overweight or obese at only one time period. Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood. Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer epidemiology, biomarkers &amp; prevention

ISSN

1055-9965

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

876-885

Kód UT WoS článku

000402765600009

EID výsledku v databázi Scopus

2-s2.0-85020232130