Electrochemical analysis of nucleic acids as potential cancer biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078123" target="_blank" >RIV/00209805:_____/19:00078123 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S245191031830262X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S245191031830262X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.coelec.2019.01.002" target="_blank" >10.1016/j.coelec.2019.01.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical analysis of nucleic acids as potential cancer biomarkers

Popis výsledku v původním jazyce

In recent years, a huge progress has been made regarding the development of electrochemical (EC) assays for detection of nucleic acids - DNA or RNA - as potential cancer biomarkers. Various ingenious strategies for determination of DNA methylation of gene promoters, circulating tumor DNAs, viral nucleic acids, or short noncoding microRNAs were presented, many of them showing remarkable sensitivities. However, a majority of these assays were not applied into clinical samples from patients, which is crucial should the electrochemistry compete with conventional, routinely used techniques. In this review, we critically evaluate strengths and weaknesses of EC assays that recognized this necessity and successfully determined endogenous DNA or RNA in patient samples with various forms of tumors.

Název v anglickém jazyce

Electrochemical analysis of nucleic acids as potential cancer biomarkers

Popis výsledku anglicky

In recent years, a huge progress has been made regarding the development of electrochemical (EC) assays for detection of nucleic acids - DNA or RNA - as potential cancer biomarkers. Various ingenious strategies for determination of DNA methylation of gene promoters, circulating tumor DNAs, viral nucleic acids, or short noncoding microRNAs were presented, many of them showing remarkable sensitivities. However, a majority of these assays were not applied into clinical samples from patients, which is crucial should the electrochemistry compete with conventional, routinely used techniques. In this review, we critically evaluate strengths and weaknesses of EC assays that recognized this necessity and successfully determined endogenous DNA or RNA in patient samples with various forms of tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Electrochemistry

ISSN

2451-9103

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

April 2019

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

96-103

Kód UT WoS článku

000471288800015

EID výsledku v databázi Scopus

2-s2.0-85061161649