Long Non-Coding RNAs in Multiple Myeloma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078377" target="_blank" >RIV/00209805:_____/19:00078377 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/19:E0107736 RIV/00216224:14110/19:00108519

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468639/pdf/ncrna-05-00013.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468639/pdf/ncrna-05-00013.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ncrna5010013" target="_blank" >10.3390/ncrna5010013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long Non-Coding RNAs in Multiple Myeloma

Popis výsledku v původním jazyce

Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.

Název v anglickém jazyce

Long Non-Coding RNAs in Multiple Myeloma

Popis výsledku anglicky

Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NV17-29343A" target="_blank" >NV17-29343A: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Non-coding RNA

ISSN

2311-553X

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

"E13"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85063964711