Long non-coding RNAs in multiple myeloma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088895" target="_blank" >RIV/00216224:14110/16:00088895 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/16:00065614

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Long non-coding RNAs in multiple myeloma

Popis výsledku v původním jazyce

Introduction Multiple myeloma (MM) is the second most common hematological malignancy in the world. It is characterized by increasing rate of various genetic mutations and dysregulated pathways. This work aims to find out if this observed dysregulation may be al least partly caused by a subgroup of non-coding RNAs, so-called long non-coding RNA molecules (lncRNA). These molecules are over 200 nt long, primarily localized in the nucleus, and it seems increasingly obvious that lncRNAs play a role in variety of cell processes, such as proliferation, differentiation and apoptosis. Also, it seems that these lncRNAs have a crucial role in the pathogenesis of a wide range of human diseases, including cancer. Therefore, it is very likely they contribute to tumor transformation and disease progression in MM.

Název v anglickém jazyce

Long non-coding RNAs in multiple myeloma

Popis výsledku anglicky

Introduction Multiple myeloma (MM) is the second most common hematological malignancy in the world. It is characterized by increasing rate of various genetic mutations and dysregulated pathways. This work aims to find out if this observed dysregulation may be al least partly caused by a subgroup of non-coding RNAs, so-called long non-coding RNA molecules (lncRNA). These molecules are over 200 nt long, primarily localized in the nucleus, and it seems increasingly obvious that lncRNAs play a role in variety of cell processes, such as proliferation, differentiation and apoptosis. Also, it seems that these lncRNAs have a crucial role in the pathogenesis of a wide range of human diseases, including cancer. Therefore, it is very likely they contribute to tumor transformation and disease progression in MM.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NV15-29508A" target="_blank" >NV15-29508A: Cirkulující nukleové kyseliny jako markery progrese mnohočetného myelomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů