PD-L1 in Squamous Cell Carcinoma of the Oral Tongue Shows Gender-Specific Association With Prognosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078402" target="_blank" >RIV/00209805:_____/20:00078402 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/32406589/?from_term=coates+pj&from_sort=date&from_pos=1" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32406589/?from_term=coates+pj&from_sort=date&from_pos=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/odi.13414" target="_blank" >10.1111/odi.13414</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PD-L1 in Squamous Cell Carcinoma of the Oral Tongue Shows Gender-Specific Association With Prognosis

Popis výsledku v původním jazyce

Objective: To use alternative quantitation approaches to clarify the clinical implication of programmed cell death ligand 1 (PD-L1) in squamous cell carcinoma of the oral tongue (SCCOT). Materials and methods: Ventana SP263 immunohistochemistry assay and a multiplicative QuickScore method were applied to quantify PD-L1 in tumor and surrounding immune cells from 101 patients with SCCOT. Tumor-infiltrating immune cells were estimated from bulk tissue transcriptional profiles of 25 patients. Circulating PD-L1 levels were measured in serum from 30 patients using an electrochemiluminescence assay platform. Results: We found higher tumor cell PD-L1 levels in females than males (P = 0.019). For patients with low PD-L1 in tumor cells, better survival was seen in males than females (overall survival P = 0.021, disease-free survival P = 0.020). Tumor-infiltrating natural killer T cells, immature dendritic cells and M1 macrophages were positively associated with tumor cell PD-L1 (P &lt; 0.05). Conclusions: Our data confirmed the significance of gender on tumor cell PD-L1 expression and demonstrated combined effects of gender and PD-L1 levels on clinical outcome in patients with SCCOT. The data also indicated the involvement of specific immune cell types in PD-L1 regulated immune evasion.

Název v anglickém jazyce

PD-L1 in Squamous Cell Carcinoma of the Oral Tongue Shows Gender-Specific Association With Prognosis

Popis výsledku anglicky

Objective: To use alternative quantitation approaches to clarify the clinical implication of programmed cell death ligand 1 (PD-L1) in squamous cell carcinoma of the oral tongue (SCCOT). Materials and methods: Ventana SP263 immunohistochemistry assay and a multiplicative QuickScore method were applied to quantify PD-L1 in tumor and surrounding immune cells from 101 patients with SCCOT. Tumor-infiltrating immune cells were estimated from bulk tissue transcriptional profiles of 25 patients. Circulating PD-L1 levels were measured in serum from 30 patients using an electrochemiluminescence assay platform. Results: We found higher tumor cell PD-L1 levels in females than males (P = 0.019). For patients with low PD-L1 in tumor cells, better survival was seen in males than females (overall survival P = 0.021, disease-free survival P = 0.020). Tumor-infiltrating natural killer T cells, immature dendritic cells and M1 macrophages were positively associated with tumor cell PD-L1 (P &lt; 0.05). Conclusions: Our data confirmed the significance of gender on tumor cell PD-L1 expression and demonstrated combined effects of gender and PD-L1 levels on clinical outcome in patients with SCCOT. The data also indicated the involvement of specific immune cell types in PD-L1 regulated immune evasion.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oral Diseases

ISSN

1354-523X

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

10

Strana od-do

"1414–1423"

Kód UT WoS článku

000545475200001

EID výsledku v databázi Scopus

2-s2.0-85087561132