Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080108" target="_blank" >RIV/00209805:_____/25:00080108 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00140486 RIV/61988987:17110/25:A26039I1 RIV/00843989:_____/25:E0111298

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2444544" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2444544</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/07853890.2024.2444544" target="_blank" >10.1080/07853890.2024.2444544</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection

Popis výsledku v původním jazyce

INTRODUCTION: It is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group. PATIENTS AND METHODS: For this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration. RESULTS: The ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +- 0.53) than for total (bound + unbound) (0.91 +- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +- 0.19 vs. 0.46 +- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio &gt; 1). The total hospital stay was significantly longer in patients with DSWI (46 +- 11.6 days) versus without DSWI (14 +- 11.7 days) (p &lt; 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years. CONCLUSION: Vancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032).

Název v anglickém jazyce

Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection

Popis výsledku anglicky

INTRODUCTION: It is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group. PATIENTS AND METHODS: For this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration. RESULTS: The ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +- 0.53) than for total (bound + unbound) (0.91 +- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +- 0.19 vs. 0.46 +- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio &gt; 1). The total hospital stay was significantly longer in patients with DSWI (46 +- 11.6 days) versus without DSWI (14 +- 11.7 days) (p &lt; 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years. CONCLUSION: Vancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of medicine

ISSN

0785-3890

e-ISSN

1365-2060

Svazek periodika

57

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

2444544

Kód UT WoS článku

001387940600001

EID výsledku v databázi Scopus

2-s2.0-85212953711