Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00141245" target="_blank" >RIV/00216224:14110/25:00141245 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s44411-025-00194-6" target="_blank" >https://link.springer.com/article/10.1007/s44411-025-00194-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-025-00194-6" target="_blank" >10.1007/s44411-025-00194-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study

Popis výsledku v původním jazyce

Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 ± 1.43) than for total clindamycin concentrations (0.83 ± 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 ± 0.35 vs. 0.81 ± 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 ± 20 days) than in those without infection (14 ± 12 days; p &lt; 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.

Název v anglickém jazyce

Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study

Popis výsledku anglicky

Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 ± 1.43) than for total clindamycin concentrations (0.83 ± 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 ± 0.35 vs. 0.81 ± 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 ± 20 days) than in those without infection (14 ± 12 days; p &lt; 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

126

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

1891-1903

Kód UT WoS článku

001495243100001

EID výsledku v databázi Scopus

2-s2.0-105006613076