Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A6372" target="_blank" >RIV/00216208:11110/10:6372 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023728:_____/10:#0000064 RIV/00064165:_____/10:6372

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage

Popis výsledku v původním jazyce

The focus of this study was to evaluate the role of prolactin (PRL) serum and synovial fluid levels in patients suffering from rheumatoid arthritis in the disease activity - clinical, laboratory and X-ray changes. A total of 29 patients with RA and 26 patients with OA were included in the study. The concentration of PRL in the serum and synovial fluid was measured by immunoradiometric assays, and the levels of serum anti-citrullinated protein/peptide autoantibodies (ACPA) and IgM rheumatoid factor (IgM-RF) were analysed by ELISA. Disease activity score (DAS 28) and radiological (Larsen) score were assessed. The levels of PRL in serum (299.55?27.28 vs. 230.59?16.61mIU/l, p=0.041) as well as in synovial fluid (338.85? 33.49 vs. 245.97?21.88mIU/l, p=0.024) were significantly higher in patients with RA than in patients with OA. The findings of increased prolactin levels in patients with RA lead to the assumption that prolactin may play a role in disease severity and the process of joint da

Název v anglickém jazyce

Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage

Popis výsledku anglicky

The focus of this study was to evaluate the role of prolactin (PRL) serum and synovial fluid levels in patients suffering from rheumatoid arthritis in the disease activity - clinical, laboratory and X-ray changes. A total of 29 patients with RA and 26 patients with OA were included in the study. The concentration of PRL in the serum and synovial fluid was measured by immunoradiometric assays, and the levels of serum anti-citrullinated protein/peptide autoantibodies (ACPA) and IgM rheumatoid factor (IgM-RF) were analysed by ELISA. Disease activity score (DAS 28) and radiological (Larsen) score were assessed. The levels of PRL in serum (299.55?27.28 vs. 230.59?16.61mIU/l, p=0.041) as well as in synovial fluid (338.85? 33.49 vs. 245.97?21.88mIU/l, p=0.024) were significantly higher in patients with RA than in patients with OA. The findings of increased prolactin levels in patients with RA lead to the assumption that prolactin may play a role in disease severity and the process of joint da

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/NR9292" target="_blank" >NR9292: Prolaktin a revmatoidní artritida</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Experimental Rheumatology

ISSN

0392-856X

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000286918800008

EID výsledku v databázi Scopus

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