The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190437" target="_blank" >RIV/00216208:11110/13:10190437 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/13:43907676 RIV/00064165:_____/13:10190437 RIV/00023728:_____/13:#0004116

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cyto.2013.05.001" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2013.05.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cyto.2013.05.001" target="_blank" >10.1016/j.cyto.2013.05.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels

Popis výsledku v původním jazyce

Objective: To assess the expression of the novel adipokine Fatty Acid Binding Protein-4 (FABP4) in synovial tissues, serum and the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationships among FABP4, disease activity and metabolic status. Methods: FABP4 levels were measured in the serum and synovial fluid of 40 patients with RA and 40 control patients with OA. The disease activity score (DAS28), C-reactive protein (CRP) levels and serum lipids were assessed in patients with RA. Immunohistochemical analysis and confocal microscopy were used to study the expression and cell-specific distribution of FABP4 in synovial tissues. Results: The age, sex and body mass index (BMI) adjusted levels of FABP4 were significantly higher in the serum (p = 0.001) and synovial fluid (p = 0.005) of patients with RA when compared to OA patients. FABP4 levels were higher in females than in males and correlated positively with body mass index (BMI) in p

Název v anglickém jazyce

The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels

Popis výsledku anglicky

Objective: To assess the expression of the novel adipokine Fatty Acid Binding Protein-4 (FABP4) in synovial tissues, serum and the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationships among FABP4, disease activity and metabolic status. Methods: FABP4 levels were measured in the serum and synovial fluid of 40 patients with RA and 40 control patients with OA. The disease activity score (DAS28), C-reactive protein (CRP) levels and serum lipids were assessed in patients with RA. Immunohistochemical analysis and confocal microscopy were used to study the expression and cell-specific distribution of FABP4 in synovial tissues. Results: The age, sex and body mass index (BMI) adjusted levels of FABP4 were significantly higher in the serum (p = 0.001) and synovial fluid (p = 0.005) of patients with RA when compared to OA patients. FABP4 levels were higher in females than in males and correlated positively with body mass index (BMI) in p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10620" target="_blank" >NS10620: Role proteinu vázajícího mastné kyseliny (FABP4) v patogenezi revmatoidní artritidy a osteoartrózy</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytokine

ISSN

1043-4666

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

BR - Brazilská federativní republika

Počet stran výsledku

7

Strana od-do

441-447

Kód UT WoS článku

000325442700063

EID výsledku v databázi Scopus

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