Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7929" target="_blank" >RIV/00216208:11110/10:7929 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/10:00350296 RIV/00216208:11130/10:6204 RIV/00064203:_____/10:6204

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

Popis výsledku v původním jazyce

Regulatory T cells (Treg) are important regulators of anti-cancer immune responses. Blood samples from 112 patients with head and neck squamous cell carcinoma (HNSCC) were analysed at the time of diagnosis with emphasis on Treg counts (CD3+ CD4+ CD25+),complete blood count and tumour markers (SCC; CEA; ?1-antitrypsin; Cyfra 21?1; C-reactive protein). Data were related to TNM classification, and course of the disease 1 year after the end tretament. The percentage of CD8+ cells increased and the CD4/CD8ratio decreased with tumour grade. The ratio of B lymphocytes decreased in patients with locoregional metastases (11.25% versus 9.22%). Treg (15.2%) and CD4+ cells (45.3%) increased, while NK cells (11.8%) decreased in HNSCC patients compared to controls(9.0%, 38.1% and 15.8%, respectively). The erythrocyte counts (4.64x1012/l versus 4.45x1012/l) and haemoglobin levels (14.58 g/dl versus 14.05 g/dl) decreased, while Treg counts (8.91% versus 15.70%) increased in patients with early recu

Název v anglickém jazyce

Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

Popis výsledku anglicky

Regulatory T cells (Treg) are important regulators of anti-cancer immune responses. Blood samples from 112 patients with head and neck squamous cell carcinoma (HNSCC) were analysed at the time of diagnosis with emphasis on Treg counts (CD3+ CD4+ CD25+),complete blood count and tumour markers (SCC; CEA; ?1-antitrypsin; Cyfra 21?1; C-reactive protein). Data were related to TNM classification, and course of the disease 1 year after the end tretament. The percentage of CD8+ cells increased and the CD4/CD8ratio decreased with tumour grade. The ratio of B lymphocytes decreased in patients with locoregional metastases (11.25% versus 9.22%). Treg (15.2%) and CD4+ cells (45.3%) increased, while NK cells (11.8%) decreased in HNSCC patients compared to controls(9.0%, 38.1% and 15.8%, respectively). The erythrocyte counts (4.64x1012/l versus 4.45x1012/l) and haemoglobin levels (14.58 g/dl versus 14.05 g/dl) decreased, while Treg counts (8.91% versus 15.70%) increased in patients with early recu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular and Molecular Medicine

ISSN

1582-1838

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

RO - Rumunsko

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000275639700037

EID výsledku v databázi Scopus

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