The steroid metabolome in lamotrigine-treated women with epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10465" target="_blank" >RIV/00216208:11110/11:10465 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/11:7153 RIV/00023761:_____/11:#0000176 RIV/00064203:_____/11:7153 RIV/00064190:_____/11:#0000268 RIV/00064165:_____/11:10465

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.steroids.2011.07.002" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2011.07.002</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The steroid metabolome in lamotrigine-treated women with epilepsy

Popis výsledku v původním jazyce

Background: Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect on the levels of other neuroactive steroid metabolites such as 3a-hydroxy-5a/b-reduced androstanes. Aim: To evaluate steroid alterations in women with epilepsy (WINE) on lamotrigine monotherapy. Subjects and methods: Eleven WWE and 11 age-matched healthy women underwent blood sampling in both phases of their menstrual cycles (MCs). The steroid metabolome, which included 30 unconjugated steroids, 17 steroid polar conjugates, gonadotropins, and sex hormone-binding globulin (SHBG), was measured using gas chromatography-mass spectrometry (GC-MS) and radioimmunoassay (RIA). Results: WWE had lower cortisol levels (status p < 0.001), but elevated levels of unconjugated 17-hydroxypregnenolone (status p < 0.001). Progesterone w

Název v anglickém jazyce

The steroid metabolome in lamotrigine-treated women with epilepsy

Popis výsledku anglicky

Background: Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect on the levels of other neuroactive steroid metabolites such as 3a-hydroxy-5a/b-reduced androstanes. Aim: To evaluate steroid alterations in women with epilepsy (WINE) on lamotrigine monotherapy. Subjects and methods: Eleven WWE and 11 age-matched healthy women underwent blood sampling in both phases of their menstrual cycles (MCs). The steroid metabolome, which included 30 unconjugated steroids, 17 steroid polar conjugates, gonadotropins, and sex hormone-binding globulin (SHBG), was measured using gas chromatography-mass spectrometry (GC-MS) and radioimmunoassay (RIA). Results: WWE had lower cortisol levels (status p < 0.001), but elevated levels of unconjugated 17-hydroxypregnenolone (status p < 0.001). Progesterone w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS9790" target="_blank" >NS9790: Neuroaktivní steroidy v diagnostice poporodních duševních poruch</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Steroids

ISSN

0039-128X

e-ISSN

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Svazek periodika

76

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1351-1357

Kód UT WoS článku

000295745500017

EID výsledku v databázi Scopus

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