Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8942" target="_blank" >RIV/00216208:11110/11:8942 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1267/ahc.11014" target="_blank" >http://dx.doi.org/10.1267/ahc.11014</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

Popis výsledku v původním jazyce

Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing. In this study antibodies against keratins-10 and -14, wide-spectrum cytokeratin, vimentin, fibronectin, and galectins-1, -2, and -3 were applied to frozen sections of skin specimens two, seven, and twenty-one days after wounding. The presence of binding sites for galectins-1, -2, -3, and -7 wasdetermined using labeled proteins as probes. Our study detected a series of alterations in galectin parameters during different phases of wound healing. Presence of galectin-1 increased during the early phase of healing, whereas galectin-3 rapidly decreased in newly formed granulation tissue. In addition, nuclear reactivity of epidermal cells for galectin-2 occurred seven days post-trauma. The dynamic regulation of galectins during epithelization intimates a role of these proteins in wou

Název v anglickém jazyce

Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

Popis výsledku anglicky

Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing. In this study antibodies against keratins-10 and -14, wide-spectrum cytokeratin, vimentin, fibronectin, and galectins-1, -2, and -3 were applied to frozen sections of skin specimens two, seven, and twenty-one days after wounding. The presence of binding sites for galectins-1, -2, -3, and -7 wasdetermined using labeled proteins as probes. Our study detected a series of alterations in galectin parameters during different phases of wound healing. Presence of galectin-1 increased during the early phase of healing, whereas galectin-3 rapidly decreased in newly formed granulation tissue. In addition, nuclear reactivity of epidermal cells for galectin-2 occurred seven days post-trauma. The dynamic regulation of galectins during epithelization intimates a role of these proteins in wou

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Histochemica et Cytochemica

ISSN

0044-5991

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

9

Strana od-do

191-199

Kód UT WoS článku

000298881100001

EID výsledku v databázi Scopus

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