Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9456" target="_blank" >RIV/00216208:11110/11:9456 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/11:9456

Výsledek na webu

<a href="http://fb.cuni.cz/file/5577/FB2011A0013.pdf" target="_blank" >http://fb.cuni.cz/file/5577/FB2011A0013.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

Popis výsledku v původním jazyce

Pregnant women are often threatened by hypertension, symptoms of preterm labor, hepatopathy and other. These complications might be consequence of genetic factors together with involvement of enviromental factors. We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exon 5 and 7 of the Pregnancy associated plasma protein-A gene in the studied group consisted of 203 women ? 79 pregnant women in time of preterm labor, 24 pregnant women suffering from preeclampsia and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of all studied groups, which lead us to the hypothesis, that these polymorphisms are not associated with our studied group of Caucasian origin. However further studies with larger group of studied subjects are needed to confirm our results.

Název v anglickém jazyce

Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

Popis výsledku anglicky

Pregnant women are often threatened by hypertension, symptoms of preterm labor, hepatopathy and other. These complications might be consequence of genetic factors together with involvement of enviromental factors. We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exon 5 and 7 of the Pregnancy associated plasma protein-A gene in the studied group consisted of 203 women ? 79 pregnant women in time of preterm labor, 24 pregnant women suffering from preeclampsia and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of all studied groups, which lead us to the hypothesis, that these polymorphisms are not associated with our studied group of Caucasian origin. However further studies with larger group of studied subjects are needed to confirm our results.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

82-85

Kód UT WoS článku

000290506000006

EID výsledku v databázi Scopus

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