Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9525" target="_blank" >RIV/00216208:11110/11:9525 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/11:10131667

Výsledek na webu

<a href="http://dx.doi.org/10.1016/antiviral.2011.09.011" target="_blank" >http://dx.doi.org/10.1016/antiviral.2011.09.011</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection

Popis výsledku v původním jazyce

Human immunodeficiency virus-1 (HIV-1) successfully escapes from host immune surveillance, vaccines and antiretroviral agents. The available antiretroviral compounds can only control viremia, but it is impossible to eliminate the virus from the organism,namely because HIV-1 provirus persists in the reservoir cells from which the virus repeatedly disseminates into new cells. Current therapeutic approaches, however, do not specifically address the stage of virus reactivation. In this paper, we show thatNormosang (heme arginate; HA) appears to possess a combination of unique properties that could help to decrease the pool of latently infected reservoir cells, while simultaneously inhibiting HIV-1 replication in newly infected cells. The stimulatory effects of HA on HIV-1 reactivation seem to involve HO-1 and generation of free radicals. Our results thus suggest a new direction to explore in treatment of HIV/AIDS disease

Název v anglickém jazyce

Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection

Popis výsledku anglicky

Human immunodeficiency virus-1 (HIV-1) successfully escapes from host immune surveillance, vaccines and antiretroviral agents. The available antiretroviral compounds can only control viremia, but it is impossible to eliminate the virus from the organism,namely because HIV-1 provirus persists in the reservoir cells from which the virus repeatedly disseminates into new cells. Current therapeutic approaches, however, do not specifically address the stage of virus reactivation. In this paper, we show thatNormosang (heme arginate; HA) appears to possess a combination of unique properties that could help to decrease the pool of latently infected reservoir cells, while simultaneously inhibiting HIV-1 replication in newly infected cells. The stimulatory effects of HA on HIV-1 reactivation seem to involve HO-1 and generation of free radicals. Our results thus suggest a new direction to explore in treatment of HIV/AIDS disease

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/GD310%2F05%2FH533" target="_blank" >GD310/05/H533: Studium infekčních chorob a jejich původců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Antiviral Research

ISSN

0166-3542

e-ISSN

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Svazek periodika

92

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

434-446

Kód UT WoS článku

000298127100005

EID výsledku v databázi Scopus

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