Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9530" target="_blank" >RIV/00216208:11110/11:9530 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/11:9530
Výsledek na webu
<a href="http://dx.doi.org/10.1111/j.1365-2710.2010.01203.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-2710.2010.01203.x</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
Popis výsledku v původním jazyce
What is known and Objective: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. Methods: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0.7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. Results and Discussion: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69.6% and mydriasis in 30.4% of the subjects. The pupillary response differed in relation to the CYP2D6genotype. A maximal difference in initial pupil diameter of 0.81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0.05) except for t
Název v anglickém jazyce
Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
Popis výsledku anglicky
What is known and Objective: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. Methods: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0.7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. Results and Discussion: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69.6% and mydriasis in 30.4% of the subjects. The pupillary response differed in relation to the CYP2D6genotype. A maximal difference in initial pupil diameter of 0.81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0.05) except for t
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Clinical Pharmacy and Therapeutics
ISSN
0269-4727
e-ISSN
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Svazek periodika
36
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
513-517
Kód UT WoS článku
000292464300008
EID výsledku v databázi Scopus
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