Cortical pattern of complex but not simple movements is affected in writer's cramp: A parametric event-related fMRI study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11514" target="_blank" >RIV/00216208:11110/12:11514 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/12:00183238 RIV/00064165:_____/12:11514

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinph.2011.08.002" target="_blank" >http://dx.doi.org/10.1016/j.clinph.2011.08.002</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cortical pattern of complex but not simple movements is affected in writer's cramp: A parametric event-related fMRI study

Popis výsledku v původním jazyce

Objective: Patients with writer's cramp (WC) were studied for differences in cortical activation during movements likely to induce WC (complex movements) and movements which rarely lead to dystonia (simple movements). Methods: Eleven WC patients (10 F, 1M, mean age 41.5 +/- (SD) 7.2 years) and eleven age matched controls were examined for Blood oxygenation-level dependent (BOLD) 1.5 T fMRI. The complex task consisted of writing a single letter or random drawing using an especially adapted joystick withthe line of trajectory visualized or hidden. The simple task consisted of self-initiated fingers flexion/extension using the affected hand. Results: Unlike the controls, WC patients performing complex movements exhibited a lower BOLD signal in the primary sensorimotor cortex and in the posterior parietal cortex bilaterally. A hypoactivation was also observed in the right secondary somatosensory area, in the right anterior insula and in the left premotor cortex (p < 0.05 corrected). No s

Název v anglickém jazyce

Cortical pattern of complex but not simple movements is affected in writer's cramp: A parametric event-related fMRI study

Popis výsledku anglicky

Objective: Patients with writer's cramp (WC) were studied for differences in cortical activation during movements likely to induce WC (complex movements) and movements which rarely lead to dystonia (simple movements). Methods: Eleven WC patients (10 F, 1M, mean age 41.5 +/- (SD) 7.2 years) and eleven age matched controls were examined for Blood oxygenation-level dependent (BOLD) 1.5 T fMRI. The complex task consisted of writing a single letter or random drawing using an especially adapted joystick withthe line of trajectory visualized or hidden. The simple task consisted of self-initiated fingers flexion/extension using the affected hand. Results: Unlike the controls, WC patients performing complex movements exhibited a lower BOLD signal in the primary sensorimotor cortex and in the posterior parietal cortex bilaterally. A hypoactivation was also observed in the right secondary somatosensory area, in the right anterior insula and in the left premotor cortex (p < 0.05 corrected). No s

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

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Svazek periodika

123

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

9

Strana od-do

755-763

Kód UT WoS článku

000301190800018

EID výsledku v databázi Scopus

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