Bone Mineral Density and Body Composition in Men With Multiple Sclerosis Chronically Treated With Low-Dose Glucocorticoids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11549" target="_blank" >RIV/00216208:11110/12:11549 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/12:10124942 RIV/00064165:_____/12:11549

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/61/61_405.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/61/61_405.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bone Mineral Density and Body Composition in Men With Multiple Sclerosis Chronically Treated With Low-Dose Glucocorticoids

Popis výsledku v původním jazyce

The aim of the study was to compare the bone mineral density (BMD) and body composition between ambulatory male MS patients and control subjects and to evaluate the relationships among body composition, motor disability, glucocorticoids (GC) use, and bone health. Body composition and BMD were measured by dual-energy X-ray absorptiometry in 104 ambulatory men with MS (mean age: 45.2 years) chronically treated with low-dose GC and in 54 healthy age-matched men. Compared to age-matched controls, MS patients had a significantly lower total body bone mineral content (TBBMC) and BMD at all measured sites except for the radius. Sixty five male MS patients (62.5%) met the criteria for osteopenia and twenty six of them (25%) for osteoporosis. The multivariate analysis showed a consistent dependence of bone measures (except whole body BMD) on BMI. The total leg lean mass % was as an independent predictor of TBBMC. The Expanded Disability Status Scale (EDSS), cumulative GC dose and age were indep

Název v anglickém jazyce

Bone Mineral Density and Body Composition in Men With Multiple Sclerosis Chronically Treated With Low-Dose Glucocorticoids

Popis výsledku anglicky

The aim of the study was to compare the bone mineral density (BMD) and body composition between ambulatory male MS patients and control subjects and to evaluate the relationships among body composition, motor disability, glucocorticoids (GC) use, and bone health. Body composition and BMD were measured by dual-energy X-ray absorptiometry in 104 ambulatory men with MS (mean age: 45.2 years) chronically treated with low-dose GC and in 54 healthy age-matched men. Compared to age-matched controls, MS patients had a significantly lower total body bone mineral content (TBBMC) and BMD at all measured sites except for the radius. Sixty five male MS patients (62.5%) met the criteria for osteopenia and twenty six of them (25%) for osteoporosis. The multivariate analysis showed a consistent dependence of bone measures (except whole body BMD) on BMI. The total leg lean mass % was as an independent predictor of TBBMC. The Expanded Disability Status Scale (EDSS), cumulative GC dose and age were indep

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10564" target="_blank" >NS10564: Denzita kostního minerálu, kostní remodelace a tělesné složení u pacientů s roztroušenou sklerózou dlouhodobě léčených glukokortikoidy: vztah k odlišným genotypům receptoru pro vitamin D</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

61

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

405-417

Kód UT WoS článku

000309194600009

EID výsledku v databázi Scopus

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