Eighteen-Year Effect of Androgen Therapy on Bone Mineral Density in Trans(gender) Men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376402" target="_blank" >RIV/00216208:11110/18:10376402 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1055/s-0043-118747" target="_blank" >https://doi.org/10.1055/s-0043-118747</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0043-118747" target="_blank" >10.1055/s-0043-118747</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eighteen-Year Effect of Androgen Therapy on Bone Mineral Density in Trans(gender) Men

Popis výsledku v původním jazyce

The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47 +/- 4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213 +/- 0.15 in trans(gender) men vs. 1.192 +/- 0.19 in females and 1.203 +/- 0.06g/cm (2) in males (p&lt;0.01)]. BMD in the hip skeleton in trans(gender) men (0.950 +/- g/cm (2) ) was statistically higher than females (0.822 +/- 0.09) but not statistically different from normal males 0.988 +/- 0.06). Circulating biochemical markers of bone formation, and resorption were not different between the trans(gender) men, and matched controls. We conclude that BMD at the hip (site rich in cortical bone) after adequate dose of testosterone therapy is higher while it is not different at the spine (trabecular bone) in trans(gender) men even after 18 years of testosterone administration.

Název v anglickém jazyce

Eighteen-Year Effect of Androgen Therapy on Bone Mineral Density in Trans(gender) Men

Popis výsledku anglicky

The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47 +/- 4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213 +/- 0.15 in trans(gender) men vs. 1.192 +/- 0.19 in females and 1.203 +/- 0.06g/cm (2) in males (p&lt;0.01)]. BMD in the hip skeleton in trans(gender) men (0.950 +/- g/cm (2) ) was statistically higher than females (0.822 +/- 0.09) but not statistically different from normal males 0.988 +/- 0.06). Circulating biochemical markers of bone formation, and resorption were not different between the trans(gender) men, and matched controls. We conclude that BMD at the hip (site rich in cortical bone) after adequate dose of testosterone therapy is higher while it is not different at the spine (trabecular bone) in trans(gender) men even after 18 years of testosterone administration.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hormone and Metabolic Research

ISSN

0018-5043

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

133-137

Kód UT WoS článku

000424159700005

EID výsledku v databázi Scopus

2-s2.0-85041524587