Plasma mannose-binding lectin is stimulated by PPAR alpha in humans
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11555" target="_blank" >RIV/00216208:11110/12:11555 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/12:11555
Výsledek na webu
<a href="http://dx.doi.org/10.1152/ajpendo.00299.2011" target="_blank" >http://dx.doi.org/10.1152/ajpendo.00299.2011</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Plasma mannose-binding lectin is stimulated by PPAR alpha in humans
Popis výsledku v původním jazyce
The peroxisome proliferator activated receptor-alpha (PPAR alpha) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPAR alpha on lipid metabolism are partially mediated by circulating proteins such as FGF21 and ANGPTL4. The present study was undertaken to screen for and identify circulating proteins produced by human liver that are under the control of PPAR alpha. Toward that aim, primary human hepatocytes were treated with the synthetic PPAR alpha agonist Wy-14643 and whole genome expression data selected for secreted proteins. Expression of FGF21, ANGPTL4, and mannose-binding lectin (MBL), a soluble mediator of innate immunity and primary component of thelectin branch of the complement system, was markedly upregulated by Wy-14643 in primary human hepatocytes. Mice express two MBL isomers, Mbl1 and Mbl2. Mbl1 mRNA was weakly induced by Wy-14643 in primary mouse hepatocytes and remained un
Název v anglickém jazyce
Plasma mannose-binding lectin is stimulated by PPAR alpha in humans
Popis výsledku anglicky
The peroxisome proliferator activated receptor-alpha (PPAR alpha) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPAR alpha on lipid metabolism are partially mediated by circulating proteins such as FGF21 and ANGPTL4. The present study was undertaken to screen for and identify circulating proteins produced by human liver that are under the control of PPAR alpha. Toward that aim, primary human hepatocytes were treated with the synthetic PPAR alpha agonist Wy-14643 and whole genome expression data selected for secreted proteins. Expression of FGF21, ANGPTL4, and mannose-binding lectin (MBL), a soluble mediator of innate immunity and primary component of thelectin branch of the complement system, was markedly upregulated by Wy-14643 in primary human hepatocytes. Mice express two MBL isomers, Mbl1 and Mbl2. Mbl1 mRNA was weakly induced by Wy-14643 in primary mouse hepatocytes and remained un
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
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Svazek periodika
302
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
"E595"-"E602"
Kód UT WoS článku
000300723500012
EID výsledku v databázi Scopus
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