Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11952" target="_blank" >RIV/00216208:11110/12:11952 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/12:00379903 RIV/61388955:_____/12:00379903 RIV/60461373:22310/12:43894599 RIV/60461373:22340/12:43894599 RIV/00064165:_____/12:11952

Výsledek na webu

<a href="https://www.jstage.jst.go.jp/article/indhealth/50/4/50_MS1274/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/indhealth/50/4/50_MS1274/_pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Popis výsledku v původním jazyce

Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 x asbestos exposure, 37 x silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography -electrospray ionization - tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT 04 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2 t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0 s1/s1). In addition, in the subjects with asbe

Název v anglickém jazyce

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Popis výsledku anglicky

Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 x asbestos exposure, 37 x silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography -electrospray ionization - tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT 04 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2 t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0 s1/s1). In addition, in the subjects with asbe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Industrial Health

ISSN

0019-8366

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

8

Strana od-do

299-306

Kód UT WoS článku

000307133500007

EID výsledku v databázi Scopus

—