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Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F18%3A10382781" target="_blank" >RIV/00064165:_____/18:10382781 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/67985858:_____/18:00493430 RIV/00216208:11110/18:10382781 RIV/00216208:11510/18:10382781 RIV/46747885:24210/18:00008848

  • Výsledek na webu

    <a href="https://doi.org/10.3390/nano8090731" target="_blank" >https://doi.org/10.3390/nano8090731</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/nano8090731" target="_blank" >10.3390/nano8090731</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers

  • Popis výsledku v původním jazyce

    Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m(3) to 1.840 mg/m(3) during nanocomposite machining processes; median particle number concentration ranged from 4.8 x 10(4) to 5.4 x 10(5) particles /cm(3). The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p &lt; 0.05). Post-shift EBC samples were higher for TNF (p &lt; 0.001), LTB4 (p &lt; 0.001), and LTE4 (p &lt; 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p &lt; 0.001), LTE4 (p &lt; 0.05), and TNF (p &lt; 0.001), in addition to pre shift LTD4 and LXB4 (both p &lt; 0.05). Spirometry documented minor, but significant, post shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.

  • Název v anglickém jazyce

    Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers

  • Popis výsledku anglicky

    Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m(3) to 1.840 mg/m(3) during nanocomposite machining processes; median particle number concentration ranged from 4.8 x 10(4) to 5.4 x 10(5) particles /cm(3). The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p &lt; 0.05). Post-shift EBC samples were higher for TNF (p &lt; 0.001), LTB4 (p &lt; 0.001), and LTE4 (p &lt; 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p &lt; 0.001), LTE4 (p &lt; 0.05), and TNF (p &lt; 0.001), in addition to pre shift LTD4 and LXB4 (both p &lt; 0.05). Spirometry documented minor, but significant, post shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30304 - Public and environmental health

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Nanomaterials

  • ISSN

    2079-4991

  • e-ISSN

  • Svazek periodika

    8

  • Číslo periodika v rámci svazku

    9

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    13

  • Strana od-do

  • Kód UT WoS článku

    000448659200099

  • EID výsledku v databázi Scopus

    2-s2.0-85053809227