Deep airway inflammation and respiratory disorders in nanocomposite workers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F18%3A00008848" target="_blank" >RIV/46747885:24210/18:00008848 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985858:_____/18:00493430 RIV/00216208:11110/18:10382781 RIV/00064165:_____/18:10382781 RIV/00216208:11510/18:10382781

Výsledek na webu

<a href="http://www.mdpi.com/2079-4991/8/9/731/pdf" target="_blank" >http://www.mdpi.com/2079-4991/8/9/731/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano8090731" target="_blank" >10.3390/nano8090731</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deep airway inflammation and respiratory disorders in nanocomposite workers

Popis výsledku v původním jazyce

Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m3 to 1.840 mg/m3 during nanocomposite machining processes; median particle number concentration ranged from 4.8 × 104 to 5.4 × 105 particles/cm3. The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p b 0.05). Post-shift EBC samples were higher for TNF (p b 0.001), LTB4 (p b 0.001), and LTE4 (p b 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p b 0.001), LTE4 (p b 0.05), and TNF (p b 0.001), in addition to pre-shift LTD4 and LXB4 (both p b 0.05). Spirometry documented minor, but significant, post-shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.

Název v anglickém jazyce

Deep airway inflammation and respiratory disorders in nanocomposite workers

Popis výsledku anglicky

Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m3 to 1.840 mg/m3 during nanocomposite machining processes; median particle number concentration ranged from 4.8 × 104 to 5.4 × 105 particles/cm3. The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p b 0.05). Post-shift EBC samples were higher for TNF (p b 0.001), LTB4 (p b 0.001), and LTE4 (p b 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p b 0.001), LTE4 (p b 0.05), and TNF (p b 0.001), in addition to pre-shift LTD4 and LXB4 (both p b 0.05). Spirometry documented minor, but significant, post-shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomaterials

ISSN

2079-4991

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

—

Kód UT WoS článku

000448659200099

EID výsledku v databázi Scopus

2-s2.0-85053809227