Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12625" target="_blank" >RIV/00216208:11110/12:12625 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68407700:21340/12:00197495 RIV/00064165:_____/12:12625
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.exer.2012.09.005" target="_blank" >http://dx.doi.org/10.1016/j.exer.2012.09.005</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas
Popis výsledku v původním jazyce
Inadequate cross-linking between collagens is a characteristic feature of keratoconus (KC). The formation of bonds between collagen and elastin fibrils is mediated by the lysyl oxidase (LOX) and 4 LOX-like enzymes. The aim of this study was to determinethe distribution of LOX and the total LOX activity (LOX and 4 LOX-like enzymes) in control and KC corneas. The distribution of LOX was clearly decreased in at least 5 of the 8 KC specimens. The most marked signal reduction was observed in the stromal matrix and in keratocytes. The signal in KC specimens revealed a more irregular pattern. Endothelial cells showed no or very weak staining in areas just beneath negative stromal tissue. The mean activity of total LOX in the KC samples was lower than in control tissue and the decrease was statistically significant (p = 0.0178). We hypothesize that the restricted LOX distribution in KC corneas, and particularly the decrease of total LOX activity in cultured keratoconic fibroblasts, is one pot
Název v anglickém jazyce
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas
Popis výsledku anglicky
Inadequate cross-linking between collagens is a characteristic feature of keratoconus (KC). The formation of bonds between collagen and elastin fibrils is mediated by the lysyl oxidase (LOX) and 4 LOX-like enzymes. The aim of this study was to determinethe distribution of LOX and the total LOX activity (LOX and 4 LOX-like enzymes) in control and KC corneas. The distribution of LOX was clearly decreased in at least 5 of the 8 KC specimens. The most marked signal reduction was observed in the stromal matrix and in keratocytes. The signal in KC specimens revealed a more irregular pattern. Endothelial cells showed no or very weak staining in areas just beneath negative stromal tissue. The mean activity of total LOX in the KC samples was lower than in control tissue and the decrease was statistically significant (p = 0.0178). We hypothesize that the restricted LOX distribution in KC corneas, and particularly the decrease of total LOX activity in cultured keratoconic fibroblasts, is one pot
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FF - ORL, oftalmologie, stomatologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GPP301%2F12%2FP591" target="_blank" >GPP301/12/P591: Identifikace a charakterizace nového genu pro endotelové dystrofie rohovky</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental Eye Research
ISSN
0014-4835
e-ISSN
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Svazek periodika
104
Číslo periodika v rámci svazku
NOV 2012
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
74-81
Kód UT WoS článku
000311133400009
EID výsledku v databázi Scopus
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