Selenium: an important trace element and therapeutic adjunct in critical care

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12918" target="_blank" >RIV/00216208:11110/12:12918 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/12:12918

Výsledek na webu

<a href="http://dx.doi.org/10.5414/TE0X1250" target="_blank" >http://dx.doi.org/10.5414/TE0X1250</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Selenium: an important trace element and therapeutic adjunct in critical care

Popis výsledku v původním jazyce

Selenium (Se) is an important micronutrient affecting multiple physiologic functions. Low Se levels observed in a general population are mainly caused by its limited availability in the diet. Se, incorporated in seleno-enzymes, plays a key role in protection against oxidative stress, a principle phenomenon in inflammatory response and sepsis. Se levels decrease early in inflammation. This decrease is probably caused by destruction of the enzymes as well as redistribution of Se, and its consumption. Se and seleno-enzyme levels correlate well with biomarkers and severity of sepsis. This observation sparked a hypothesis that Se supplementation would restore Se levels, improving the morbidity and mortality in sepsis. Standard-dose supplementation did not normalize Se levels. In contrast, high-dose supplementation in systemic inflammation and sepsis restored Se levels and improved some biomarkers of sepsis in several small-scale early studies. Similar benefits were observed in both experime

Název v anglickém jazyce

Selenium: an important trace element and therapeutic adjunct in critical care

Popis výsledku anglicky

Selenium (Se) is an important micronutrient affecting multiple physiologic functions. Low Se levels observed in a general population are mainly caused by its limited availability in the diet. Se, incorporated in seleno-enzymes, plays a key role in protection against oxidative stress, a principle phenomenon in inflammatory response and sepsis. Se levels decrease early in inflammation. This decrease is probably caused by destruction of the enzymes as well as redistribution of Se, and its consumption. Se and seleno-enzyme levels correlate well with biomarkers and severity of sepsis. This observation sparked a hypothesis that Se supplementation would restore Se levels, improving the morbidity and mortality in sepsis. Standard-dose supplementation did not normalize Se levels. In contrast, high-dose supplementation in systemic inflammation and sepsis restored Se levels and improved some biomarkers of sepsis in several small-scale early studies. Similar benefits were observed in both experime

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trace Elements and Electrolytes

ISSN

0946-2104

e-ISSN

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Svazek periodika

29

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

246-255

Kód UT WoS článku

000311070200004

EID výsledku v databázi Scopus

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