Laparoscopic Sleeve Gastrectomy Differentially Affects Serum Concentrations of FGF-19 and FGF-21 in Morbidly Obese Subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10172643" target="_blank" >RIV/00216208:11110/13:10172643 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/13:0023 RIV/00064165:_____/13:10172643

Výsledek na webu

<a href="http://dx.doi.org/10.1002/oby.20208" target="_blank" >http://dx.doi.org/10.1002/oby.20208</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/oby.20208" target="_blank" >10.1002/oby.20208</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Laparoscopic Sleeve Gastrectomy Differentially Affects Serum Concentrations of FGF-19 and FGF-21 in Morbidly Obese Subjects

Popis výsledku v původním jazyce

Objective: Fibroblast growth factor (FGF)-19 and FGF-21 are novel metabolic regulators that improve insulin resistance and obesity in rodents. The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrationsof FGF-19 and FGF-21 along with circulating bile acids and other relevant hormonal and biochemical parameters. Design and Methods: Seventeen females with obesity undergoing LSG and 15 lean healthy females were included into the study. Anthropometric andbiochemical parameters, serum concentrations of FGF-19 and -21, insulin, adiponectin, leptin, C-reactive protein, resistin, amylin (total), ghrelin (active), glucagon-like peptide 1 (GLP-1, active), glucose-dependent insulinotropic peptide (GIP, total),peptide YY (PYY, total), pancreatic polypeptide (PP), and bile acids, and mRNA expression of selected adipokines and inflammatory markers in bioptic samples of subcutaneous fat were assessed at baseline and 6, 12, and 24 months after LSG

Název v anglickém jazyce

Laparoscopic Sleeve Gastrectomy Differentially Affects Serum Concentrations of FGF-19 and FGF-21 in Morbidly Obese Subjects

Popis výsledku anglicky

Objective: Fibroblast growth factor (FGF)-19 and FGF-21 are novel metabolic regulators that improve insulin resistance and obesity in rodents. The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrationsof FGF-19 and FGF-21 along with circulating bile acids and other relevant hormonal and biochemical parameters. Design and Methods: Seventeen females with obesity undergoing LSG and 15 lean healthy females were included into the study. Anthropometric andbiochemical parameters, serum concentrations of FGF-19 and -21, insulin, adiponectin, leptin, C-reactive protein, resistin, amylin (total), ghrelin (active), glucagon-like peptide 1 (GLP-1, active), glucose-dependent insulinotropic peptide (GIP, total),peptide YY (PYY, total), pancreatic polypeptide (PP), and bile acids, and mRNA expression of selected adipokines and inflammatory markers in bioptic samples of subcutaneous fat were assessed at baseline and 6, 12, and 24 months after LSG

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Obesity

ISSN

1930-7381

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1335-1342

Kód UT WoS článku

000323351400005

EID výsledku v databázi Scopus

—