Pre- and/or Postsurgical Administration of Estradiol Benzoate Increases Skin Flap Viability in Female Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10174150" target="_blank" >RIV/00216208:11110/13:10174150 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00266-013-0151-z" target="_blank" >http://dx.doi.org/10.1007/s00266-013-0151-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00266-013-0151-z" target="_blank" >10.1007/s00266-013-0151-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pre- and/or Postsurgical Administration of Estradiol Benzoate Increases Skin Flap Viability in Female Rats

Popis výsledku v původním jazyce

It has been shown that estrogens have a protective effect with regard to tissue ischemia. Therefore, in this macroscopic and histological investigation, the effect of estradiol benzoate on skin flap viability was studied in sham-operated and ovariectomized Sprague-Dawley rats. Three months prior to flap surgery a group of rats underwent ovariectomy, while the remaining animals underwent a sham operation. Subsequently, all rats had a 2 x 8-cm skin flap created on the dorsum. Rats were randomly divided into estradiol- or saline-treated groups. Treatment started either on the day of flap excision or 3 days prior to the surgery. Our results showed that administration of estradiol benzoate prior to and after flap surgery significantly decreases skin flap necrosis in both sham-operated and ovariectomized rats, with the highest survival rate in animals where treatment started 3 days prior to flap surgery. In conclusion, the observed protective effect of estradiol on skin flap viability could

Název v anglickém jazyce

Pre- and/or Postsurgical Administration of Estradiol Benzoate Increases Skin Flap Viability in Female Rats

Popis výsledku anglicky

It has been shown that estrogens have a protective effect with regard to tissue ischemia. Therefore, in this macroscopic and histological investigation, the effect of estradiol benzoate on skin flap viability was studied in sham-operated and ovariectomized Sprague-Dawley rats. Three months prior to flap surgery a group of rats underwent ovariectomy, while the remaining animals underwent a sham operation. Subsequently, all rats had a 2 x 8-cm skin flap created on the dorsum. Rats were randomly divided into estradiol- or saline-treated groups. Treatment started either on the day of flap excision or 3 days prior to the surgery. Our results showed that administration of estradiol benzoate prior to and after flap surgery significantly decreases skin flap necrosis in both sham-operated and ovariectomized rats, with the highest survival rate in animals where treatment started 3 days prior to flap surgery. In conclusion, the observed protective effect of estradiol on skin flap viability could

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aesthetic Plastic Surgery

ISSN

0364-216X

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1003-1009

Kód UT WoS článku

000324326300025

EID výsledku v databázi Scopus

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