Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188756" target="_blank" >RIV/00216208:11110/13:10188756 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10237-012-0461-0" target="_blank" >http://dx.doi.org/10.1007/s10237-012-0461-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10237-012-0461-0" target="_blank" >10.1007/s10237-012-0461-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle

Popis výsledku v původním jazyce

Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology from confocal images and analyzed with finite element techniques. Measured material properties and intraventricular pressures were specified in the models. The results show volume-weighted end-diastolic von Mises stress and strain averaging 50-82 % higher in the trabecular tissue than in the compact wall. T

Název v anglickém jazyce

Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle

Popis výsledku anglicky

Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology from confocal images and analyzed with finite element techniques. Measured material properties and intraventricular pressures were specified in the models. The results show volume-weighted end-diastolic von Mises stress and strain averaging 50-82 % higher in the trabecular tissue than in the compact wall. T

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomechanics and Modeling in Mechanobiology

ISSN

1617-7959

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

15

Strana od-do

1037-1051

Kód UT WoS článku

000324378900013

EID výsledku v databázi Scopus

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