Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189655" target="_blank" >RIV/00216208:11110/13:10189655 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985807:_____/13:00425961 RIV/00216208:11310/13:10189655
Výsledek na webu
<a href="http://fb.cuni.cz/file/5699/FB2013A0026.pdf" target="_blank" >http://fb.cuni.cz/file/5699/FB2013A0026.pdf</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction
Popis výsledku v původním jazyce
The myocardial extracellular matrix plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in post-myocardial infarction repair processes. We analysed some genetic and proteomic aspects thatcould play an important role in the development of myocardial infarction. Matrix metalloproteinases are enzymes that contribute strongly to the degradation of extracellular matrix components. In this study the serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects. The serum levels of WIMPs were determined by ELISA. Changes in serum levels were characterized within 24 h and after 6 months post myocardial infarction. Significantly higher levels of MMP-2 (299.47 +/- 117.61 ng/ml) and MMP-9 (93.56 +/- 53.74 ng/ml) were determined in patients with myocardial infarction compared to the controls, in both cases P < 0.001. MMP-9 levels decreas
Název v anglickém jazyce
Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction
Popis výsledku anglicky
The myocardial extracellular matrix plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in post-myocardial infarction repair processes. We analysed some genetic and proteomic aspects thatcould play an important role in the development of myocardial infarction. Matrix metalloproteinases are enzymes that contribute strongly to the degradation of extracellular matrix components. In this study the serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects. The serum levels of WIMPs were determined by ELISA. Changes in serum levels were characterized within 24 h and after 6 months post myocardial infarction. Significantly higher levels of MMP-2 (299.47 +/- 117.61 ng/ml) and MMP-9 (93.56 +/- 53.74 ng/ml) were determined in patients with myocardial infarction compared to the controls, in both cases P < 0.001. MMP-9 levels decreas
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/1M06014" target="_blank" >1M06014: Centrum biomedicínské informatiky (CBI)</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Folia Biologica
ISSN
0015-5500
e-ISSN
—
Svazek periodika
59
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
7
Strana od-do
181-187
Kód UT WoS článku
000327577300002
EID výsledku v databázi Scopus
—