Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190200" target="_blank" >RIV/00216208:11110/13:10190200 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/13:#0000399 RIV/00064165:_____/13:10190200

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.regpep.2012.12.010" target="_blank" >http://dx.doi.org/10.1016/j.regpep.2012.12.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.regpep.2012.12.010" target="_blank" >10.1016/j.regpep.2012.12.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Popis výsledku v původním jazyce

Objective: Free fatty acids (FFA)-adrenocorticotropin (ACTH) feedback loop between adipose tissue and the hypothalamic-pituitary centers in the brain has been suggested to be affected by the exercise and by administration of anti-lipolytic drugs. Also leptin may be affected by exercise. Dysfunction of FFA-leptin-ACTH secretion might be involved in binge eating and subsequent purging as is the case in bulimia nervosa (BN). Methods: In the present single-blind, randomized study, we explored responses of plasma ACTH, leptin and FFA concentrations to exercise (45 min, 2 W/kg of lean body mass [LBM]) with Acipimox (Aci), an anti-lipolytic nicotinic acid analog, or placebo randomly received in nine women with EN and nine healthy women. In conclusion, Aci canbe considered acceptable in the treatment of eating disorders, and it may also serve as an alternative low-dose dexamethasone suppression test (LDDST) in these patients. Trial registration: Australia and New Zealand Clinical Trials Regis

Název v anglickém jazyce

Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Popis výsledku anglicky

Objective: Free fatty acids (FFA)-adrenocorticotropin (ACTH) feedback loop between adipose tissue and the hypothalamic-pituitary centers in the brain has been suggested to be affected by the exercise and by administration of anti-lipolytic drugs. Also leptin may be affected by exercise. Dysfunction of FFA-leptin-ACTH secretion might be involved in binge eating and subsequent purging as is the case in bulimia nervosa (BN). Methods: In the present single-blind, randomized study, we explored responses of plasma ACTH, leptin and FFA concentrations to exercise (45 min, 2 W/kg of lean body mass [LBM]) with Acipimox (Aci), an anti-lipolytic nicotinic acid analog, or placebo randomly received in nine women with EN and nine healthy women. In conclusion, Aci canbe considered acceptable in the treatment of eating disorders, and it may also serve as an alternative low-dose dexamethasone suppression test (LDDST) in these patients. Trial registration: Australia and New Zealand Clinical Trials Regis

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NR9158" target="_blank" >NR9158: Postprandiální odpověď ghrelinu a dalších hormonů s účastí v regulaci příjmu potravy u pacientek s anorexia nervosa a bulimia nervosa</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Regulatory Peptides

ISSN

0167-0115

e-ISSN

—

Svazek periodika

182

Číslo periodika v rámci svazku

Mar

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

45-52

Kód UT WoS článku

000317455200008

EID výsledku v databázi Scopus

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