Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192278" target="_blank" >RIV/00216208:11110/13:10192278 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1042/CS20120661" target="_blank" >http://dx.doi.org/10.1042/CS20120661</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/CS20120661" target="_blank" >10.1042/CS20120661</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
Popis výsledku v původním jazyce
Recent epidemiological and clinical data show protection from CVD, all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low-
Název v anglickém jazyce
Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
Popis výsledku anglicky
Recent epidemiological and clinical data show protection from CVD, all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low-
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Clinical Science
ISSN
0143-5221
e-ISSN
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Svazek periodika
125
Číslo periodika v rámci svazku
5-6
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
257-264
Kód UT WoS článku
000322504400004
EID výsledku v databázi Scopus
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