Steatóza jater je nezávisle spojena se změnami v cirkulujících HDL2 a HDL3 subfrakcích

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F08%3A00007830" target="_blank" >RIV/00216275:25310/08:00007830 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fatty Liver is independently associated with alterations in circulating HDL2 and HDL3 Subfractions

Popis výsledku v původním jazyce

Fatty Liver is associated with insulin resistance, atherosclerosis and the metabolic syndrome and predicts future cardiovascular events. The pro-atherogenic serum lipid profile in subjects with fatty liver is characterized by elevated levels of triglycerides, low high-density lipoprotein cholesterol (HDL-C) and an increase in small, dense low-density lipoprotein (LDL) particles. Regarding HDL, not only quantitative, but also qualitative and compositional alterations are related to its antiatherogenic properties. Particularly circulating HDL2 was found to protect from atherosclerosis. In the present study we investigated first, whether fatty liver is associated with altered circulating HDL-C subfractions and second whether this relationship is independent of insulin sensitivity, thus possibly representing a direct link between fatty liver and cardiovascular disease.

Název v anglickém jazyce

Fatty Liver is independently associated with alterations in circulating HDL2 and HDL3 Subfractions

Popis výsledku anglicky

Fatty Liver is associated with insulin resistance, atherosclerosis and the metabolic syndrome and predicts future cardiovascular events. The pro-atherogenic serum lipid profile in subjects with fatty liver is characterized by elevated levels of triglycerides, low high-density lipoprotein cholesterol (HDL-C) and an increase in small, dense low-density lipoprotein (LDL) particles. Regarding HDL, not only quantitative, but also qualitative and compositional alterations are related to its antiatherogenic properties. Particularly circulating HDL2 was found to protect from atherosclerosis. In the present study we investigated first, whether fatty liver is associated with altered circulating HDL-C subfractions and second whether this relationship is independent of insulin sensitivity, thus possibly representing a direct link between fatty liver and cardiovascular disease.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Care

ISSN

0149-5992

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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