Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193014" target="_blank" >RIV/00216208:11110/13:10193014 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/13:10193014

Výsledek na webu

<a href="http://dx.doi.org/10.1136/jnnp-2012-304740" target="_blank" >http://dx.doi.org/10.1136/jnnp-2012-304740</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/jnnp-2012-304740" target="_blank" >10.1136/jnnp-2012-304740</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event

Popis výsledku v původním jazyce

Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon ?-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon ?-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine,25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first rel

Název v anglickém jazyce

Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event

Popis výsledku anglicky

Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon ?-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon ?-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine,25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first rel

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurology, Neurosurgery and Psychiatry

ISSN

0022-3050

e-ISSN

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Svazek periodika

84

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1186-1191

Kód UT WoS článku

000329373100230

EID výsledku v databázi Scopus

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