Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272326" target="_blank" >RIV/00216208:11110/14:10272326 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10272326

Výsledek na webu

<a href="http://dx.doi.org/10.1136/jnnp-2013-307106" target="_blank" >http://dx.doi.org/10.1136/jnnp-2013-307106</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/jnnp-2013-307106" target="_blank" >10.1136/jnnp-2013-307106</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

Popis výsledku v původním jazyce

Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1+-SD 8.1 years). All patients were treated with intramuscular interferon-? as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-? treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (p<0.001) and increased number of new or enlarging T2 lesions (p<0.001

Název v anglickém jazyce

Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

Popis výsledku anglicky

Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1+-SD 8.1 years). All patients were treated with intramuscular interferon-? as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-? treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (p<0.001) and increased number of new or enlarging T2 lesions (p<0.001

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurology, Neurosurgery and Psychiatry

ISSN

0022-3050

e-ISSN

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Svazek periodika

85

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

860-865

Kód UT WoS článku

000342428500052

EID výsledku v databázi Scopus

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