Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193024" target="_blank" >RIV/00216208:11110/13:10193024 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/13:10193024 RIV/00669806:_____/13:10193024 RIV/00064165:_____/13:10193024
Výsledek na webu
<a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >http://dx.doi.org/10.3109/01902148.2012.737404</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/01902148.2012.737404" target="_blank" >10.3109/01902148.2012.737404</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs
Popis výsledku v původním jazyce
The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitricoxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Conc
Název v anglickém jazyce
Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1 beta proteins in pigs
Popis výsledku anglicky
The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-alpha, MIP-1 beta, nitrites/nitrates, and inducible nitricoxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-alpha increased significantly in group III during the second and third hour (P = .01). Conc
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental Lung Research
ISSN
0190-2148
e-ISSN
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Svazek periodika
39
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
8
Strana od-do
1-8
Kód UT WoS článku
000313682100001
EID výsledku v databázi Scopus
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