DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195209" target="_blank" >RIV/00216208:11110/13:10195209 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023736:_____/13:00010674 RIV/00064165:_____/13:10195209
Výsledek na webu
<a href="http://dx.doi.org/10.1186/1756-8722-6-9" target="_blank" >http://dx.doi.org/10.1186/1756-8722-6-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1756-8722-6-9" target="_blank" >10.1186/1756-8722-6-9</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
Popis výsledku v původním jazyce
Background: Interactions between genetic variants and risk factors in myelodysplastic syndromes are poorly understood. In this case-control study, we analyzed 1 421 single nucleotide polymorphisms in 408 genes involved in cancer-related pathways in 198 patients and 292 controls. Methods: The Illumina SNP Cancer Panel was used for genotyping of samples. The chi-squared, p-values, odds ratios and upper and lower limits of the 95% confidence interval were calculated for all the SNPs that passed the qualitycontrol filtering. Results: Gene-based analysis showed nine candidate single nucleotide polymorphisms significantly associated with the disease susceptibility (q-value < 0.05). Four of these polymorphisms were located in oxidative damage/DNA repair genes (LIG1, RAD52, MSH3 and GPX3), which may play important roles in the pathobiology of myelodysplastic syndromes. Two of nine candidate polymorphisms were located in transmembrane transporters (ABCB1 and SLC4A2), contributing to individual
Název v anglickém jazyce
DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
Popis výsledku anglicky
Background: Interactions between genetic variants and risk factors in myelodysplastic syndromes are poorly understood. In this case-control study, we analyzed 1 421 single nucleotide polymorphisms in 408 genes involved in cancer-related pathways in 198 patients and 292 controls. Methods: The Illumina SNP Cancer Panel was used for genotyping of samples. The chi-squared, p-values, odds ratios and upper and lower limits of the 95% confidence interval were calculated for all the SNPs that passed the qualitycontrol filtering. Results: Gene-based analysis showed nine candidate single nucleotide polymorphisms significantly associated with the disease susceptibility (q-value < 0.05). Four of these polymorphisms were located in oxidative damage/DNA repair genes (LIG1, RAD52, MSH3 and GPX3), which may play important roles in the pathobiology of myelodysplastic syndromes. Two of nine candidate polymorphisms were located in transmembrane transporters (ABCB1 and SLC4A2), contributing to individual
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT13899" target="_blank" >NT13899: SEKVENOVÁNÍ NOVÉ GENERACE JAKO NÁSTROJ PERSONÁLNÍ MEDICÍNY U PACIENTŮ S MYELODYSPLASTICKÝM SYNDROMEM A CHRONICKOU MYELOIDNÍ LEUKÉMIÍ.</a><br>
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Hematology and Oncology
ISSN
1756-8722
e-ISSN
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Svazek periodika
6
Číslo periodika v rámci svazku
Jan 22
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
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Kód UT WoS článku
000315292400001
EID výsledku v databázi Scopus
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