Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10210039" target="_blank" >RIV/00216208:11110/13:10210039 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00392100

Výsledek na webu

<a href="http://dx.doi.org/10.1093/cvr/cvs329" target="_blank" >http://dx.doi.org/10.1093/cvr/cvs329</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/cvr/cvs329" target="_blank" >10.1093/cvr/cvs329</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

Popis výsledku v původním jazyce

Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause disease remain mostly unclear. Here, we used comparative genomics between human and an established rat model of hypertension to explore the transcriptional mechanisms mediating the effect of genes identified in 15hypertension GWAS. Time series analysis of radiotelemetric blood pressure (BP) was performed to assess 11 parameters of BP variation in recombinant inbred strains derived from the spontaneously hypertensive rat. BP data were integrated with approximate to 27 000 expression quantative trait loci (eQTLs) mapped across seven tissues, detecting 8000 significant associations between eQTL genes and BP variation in the rat. We then compiled a large catalogue of human genes from GWAS of hyperten

Název v anglickém jazyce

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

Popis výsledku anglicky

Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause disease remain mostly unclear. Here, we used comparative genomics between human and an established rat model of hypertension to explore the transcriptional mechanisms mediating the effect of genes identified in 15hypertension GWAS. Time series analysis of radiotelemetric blood pressure (BP) was performed to assess 11 parameters of BP variation in recombinant inbred strains derived from the spontaneously hypertensive rat. BP data were integrated with approximate to 27 000 expression quantative trait loci (eQTLs) mapped across seven tissues, detecting 8000 significant associations between eQTL genes and BP variation in the rat. We then compiled a large catalogue of human genes from GWAS of hyperten

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiovascular Research

ISSN

0008-6363

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

653-665

Kód UT WoS článku

000315629700008

EID výsledku v databázi Scopus

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