A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10218646" target="_blank" >RIV/00216208:11110/14:10218646 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68407700:21230/14:00217849 RIV/00064165:_____/14:10218646
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s00702-014-1158-6" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1158-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00702-014-1158-6" target="_blank" >10.1007/s00702-014-1158-6</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
Popis výsledku v původním jazyce
A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia witha previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships
Název v anglickém jazyce
A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
Popis výsledku anglicky
A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia witha previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Neural Transmission
ISSN
0300-9564
e-ISSN
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Svazek periodika
121
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
AT - Rakouská republika
Počet stran výsledku
10
Strana od-do
655-664
Kód UT WoS článku
000336305100011
EID výsledku v databázi Scopus
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