Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: Results from the Multi-Center SET study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10271650" target="_blank" >RIV/00216208:11110/14:10271650 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10271650

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jneuroim.2014.04.012" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2014.04.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jneuroim.2014.04.012" target="_blank" >10.1016/j.jneuroim.2014.04.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: Results from the Multi-Center SET study

Popis výsledku v původním jazyce

Objectives: To investigate the associations between antibody responses to herpesviruses and the development of thalamic, total deep graymatter, cortical and central atrophy in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods:We analyzed volumetric brain outcomes in 193 CIS patients enrolled in amulti-center study of high-risk CIS. All patients had 2 or more MRI brain lesions and two or more oligoclonal bands in cerebrospinal fluid. Serum samples obtained at thescreening visit prior to any treatment were analyzed for IgG antibodies against cytomegalovirus (anti-CMV) and Epstein-Barr virus (EBV) viral capsid antigen (VCA). All patients were treated with interferon-beta. Clinical and MRI assessments were obtainedat baseline, 6, 12, and 24 months. Results: Anti-EBV VCA highest quartile status was associatedwith regional atrophymeasures for percent decrease in thalamus. Anti-CMV positivity was associated with greater total deep gray matter atrophy

Název v anglickém jazyce

Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: Results from the Multi-Center SET study

Popis výsledku anglicky

Objectives: To investigate the associations between antibody responses to herpesviruses and the development of thalamic, total deep graymatter, cortical and central atrophy in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods:We analyzed volumetric brain outcomes in 193 CIS patients enrolled in amulti-center study of high-risk CIS. All patients had 2 or more MRI brain lesions and two or more oligoclonal bands in cerebrospinal fluid. Serum samples obtained at thescreening visit prior to any treatment were analyzed for IgG antibodies against cytomegalovirus (anti-CMV) and Epstein-Barr virus (EBV) viral capsid antigen (VCA). All patients were treated with interferon-beta. Clinical and MRI assessments were obtainedat baseline, 6, 12, and 24 months. Results: Anti-EBV VCA highest quartile status was associatedwith regional atrophymeasures for percent decrease in thalamus. Anti-CMV positivity was associated with greater total deep gray matter atrophy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuroimmunology

ISSN

0165-5728

e-ISSN

—

Svazek periodika

273

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

58-64

Kód UT WoS článku

000340316800007

EID výsledku v databázi Scopus

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