Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189797" target="_blank" >RIV/00216208:11110/13:10189797 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/13:10189797
Výsledek na webu
<a href="http://dx.doi.org/10.1371/journal.pone.0053996" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0053996</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0053996" target="_blank" >10.1371/journal.pone.0053996</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study
Popis výsledku v původním jazyce
Objectives: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: We analyzed 211 CIS patients (age: 28.9 +/- 7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. Results: The time to first relapse decreased and the
Název v anglickém jazyce
Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study
Popis výsledku anglicky
Objectives: To investigate the associations of environmental MS risk factors with clinical and MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: We analyzed 211 CIS patients (age: 28.9 +/- 7.8 years) enrolled in the SET study, a multi-center study of high-risk CIS patients. Pre-treatment samples were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) early nuclear antigen-1 (EBNA-1), viral capsid antigen (VCA), early antigen-diffuse (EA-D), 25 hydroxy-vitamin D3 and cotinine levels and HLA DRB1*1501 status. The inclusion criteria required evaluation within 4 months of the initial demyelinating event, 2 or more brain MRI lesions and the presence of two or more oligoclonal bands in cerebrospinal fluid. All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. Results: The time to first relapse decreased and the
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
PLoS ONE
ISSN
1932-6203
e-ISSN
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Svazek periodika
8
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
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Kód UT WoS článku
000313429800079
EID výsledku v databázi Scopus
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