Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272173" target="_blank" >RIV/00216208:11110/14:10272173 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00438496 RIV/00216208:11310/14:10272173

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/463123" target="_blank" >http://dx.doi.org/10.1155/2014/463123</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/463123" target="_blank" >10.1155/2014/463123</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

Popis výsledku v původním jazyce

The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedlyincreased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development.

Název v anglickém jazyce

Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

Popis výsledku anglicky

The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedlyincreased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP302%2F11%2F1308" target="_blank" >GAP302/11/1308: Epigenetické faktory ve formování myokardu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed Research International

ISSN

2314-6133

e-ISSN

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Svazek periodika

neuveden

Číslo periodika v rámci svazku

Jun

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000338534700001

EID výsledku v databázi Scopus

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