Hypothalamo-pituitary-adrenal axis, glucose metabolism and TNF-alpha in narcolepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272222" target="_blank" >RIV/00216208:11110/14:10272222 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10272222

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jsr.12138" target="_blank" >http://dx.doi.org/10.1111/jsr.12138</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jsr.12138" target="_blank" >10.1111/jsr.12138</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hypothalamo-pituitary-adrenal axis, glucose metabolism and TNF-alpha in narcolepsy

Popis výsledku v původním jazyce

Narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism. In this case-control study, 11 patients with narcolepsy with cataplexy and 11 healthy adults underwent an oral glucose tolerance test, and dexamethasone suppression/corticotropin-releasing hormone stimulation test. The average age of patients and controls was 35.1 +/- 13.2 and 41.0 +/- 2.9 years, respectively, body mass index was 28.1 +/- 6.6 and 25.5 +/- 4.7 kg m(-2). We did not find evidence of a significantly increased prevalence of disturbed glucose tolerance in patients with narcolepsy. After hypothalamo-pituitary-adrenal axis suppression, the number of non-suppressors did not differ between the groups, indicating normal negative feedback sensitivity. The level of cortisol after dexamethasone suppression was significantly lower in patients with narcolepsy, suggesting a slight basal

Název v anglickém jazyce

Hypothalamo-pituitary-adrenal axis, glucose metabolism and TNF-alpha in narcolepsy

Popis výsledku anglicky

Narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism. In this case-control study, 11 patients with narcolepsy with cataplexy and 11 healthy adults underwent an oral glucose tolerance test, and dexamethasone suppression/corticotropin-releasing hormone stimulation test. The average age of patients and controls was 35.1 +/- 13.2 and 41.0 +/- 2.9 years, respectively, body mass index was 28.1 +/- 6.6 and 25.5 +/- 4.7 kg m(-2). We did not find evidence of a significantly increased prevalence of disturbed glucose tolerance in patients with narcolepsy. After hypothalamo-pituitary-adrenal axis suppression, the number of non-suppressors did not differ between the groups, indicating normal negative feedback sensitivity. The level of cortisol after dexamethasone suppression was significantly lower in patients with narcolepsy, suggesting a slight basal

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13238" target="_blank" >NT13238: Narkolepsie – klinika, patofyziologie, stárnutí, komorbidity a pohybový režim.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Sleep Research

ISSN

0962-1105

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

425-431

Kód UT WoS článku

000340256000008

EID výsledku v databázi Scopus

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