The Relationship Between Serum Bilirubin and Crohn's Disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282166" target="_blank" >RIV/00216208:11110/14:10282166 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10282166 RIV/00216208:11160/14:10282166 RIV/00064203:_____/14:10282166
Výsledek na webu
<a href="http://journals.lww.com/ibdjournal/Fulltext/2014/03000/The_Relationship_Between_Serum_Bilirubin_and.7.aspx" target="_blank" >http://journals.lww.com/ibdjournal/Fulltext/2014/03000/The_Relationship_Between_Serum_Bilirubin_and.7.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/01.MIB.0000440817.84251.98" target="_blank" >10.1097/01.MIB.0000440817.84251.98</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Relationship Between Serum Bilirubin and Crohn's Disease
Popis výsledku v původním jazyce
Background: The oxidative stress is thought to play an important role in Crohn's disease (CD). As serum bilirubin represents the major endogenous antioxidant, this article aimed to evaluate in a clinical study, whether serum bilirubin levels and genes affecting its systemic concentrations are associated with CD. Methods: This exploratory case-control study was based on pediatric (n = 119) and adult (n = 504) patients with CD and 370 appropriate healthy control subjects. The (GT)(n) and (TA)(n) dinucleotide variations in heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) gene promoters were determined by fragment analysis. Serum bilirubin levels were compared in a subset of 90 cases and 229 controls, for whom biochemical data were available. Results: Substantially lower serum bilirubin levels were detected in patients with CD compared with controls (7.4 versus 12.1 mu mol/L, P < 10(-6)). Serum bilirubin levels were significantly lower in patients with CD within
Název v anglickém jazyce
The Relationship Between Serum Bilirubin and Crohn's Disease
Popis výsledku anglicky
Background: The oxidative stress is thought to play an important role in Crohn's disease (CD). As serum bilirubin represents the major endogenous antioxidant, this article aimed to evaluate in a clinical study, whether serum bilirubin levels and genes affecting its systemic concentrations are associated with CD. Methods: This exploratory case-control study was based on pediatric (n = 119) and adult (n = 504) patients with CD and 370 appropriate healthy control subjects. The (GT)(n) and (TA)(n) dinucleotide variations in heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) gene promoters were determined by fragment analysis. Serum bilirubin levels were compared in a subset of 90 cases and 229 controls, for whom biochemical data were available. Results: Substantially lower serum bilirubin levels were detected in patients with CD compared with controls (7.4 versus 12.1 mu mol/L, P < 10(-6)). Serum bilirubin levels were significantly lower in patients with CD within
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FE - Ostatní obory vnitřního lékařství
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Inflammatory Bowel Diseases
ISSN
1078-0998
e-ISSN
—
Svazek periodika
20
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
481-487
Kód UT WoS článku
000335650700007
EID výsledku v databázi Scopus
—