Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10416315" target="_blank" >RIV/00216208:11110/20:10416315 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/20:N0000038 RIV/00023001:_____/20:00080273 RIV/00064165:_____/20:10416315

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pXvnKMu9q1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pXvnKMu9q1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1253/circj.CJ-20-0192" target="_blank" >10.1253/circj.CJ-20-0192</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males

Popis výsledku v původním jazyce

Background: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). Methods and Results: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. The UGT1A1 promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 mu mol/L (10.7 and 11.3 mu mol/L in males, and 8.3 and 8.8 mu mol/L in females; P&lt;0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P&lt;0.01). The UGT1A1 (TA) 7/7 promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 mu mol/L; P&lt;0.01), with almost 5-fold lower prevalence of GS. Conclusions: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.

Název v anglickém jazyce

Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males

Popis výsledku anglicky

Background: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). Methods and Results: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. The UGT1A1 promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 mu mol/L (10.7 and 11.3 mu mol/L in males, and 8.3 and 8.8 mu mol/L in females; P&lt;0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P&lt;0.01). The UGT1A1 (TA) 7/7 promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 mu mol/L; P&lt;0.01), with almost 5-fold lower prevalence of GS. Conclusions: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Circulation Journal

ISSN

1346-9843

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

7

Strana od-do

1779-1785

Kód UT WoS článku

000575438200016

EID výsledku v databázi Scopus

2-s2.0-85091807701