Elite athletes have significantly elevated serum bilirubin concentrations.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49366378%3A_____%2F22%3AN0000003" target="_blank" >RIV/49366378:_____/22:N0000003 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ecss2006.com/asp/congress/TOOLS/Benefits/EDSS_Results.asp" target="_blank" >https://www.ecss2006.com/asp/congress/TOOLS/Benefits/EDSS_Results.asp</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Elite athletes have significantly elevated serum bilirubin concentrations.

Popis výsledku v původním jazyce

INTRODUCTION: Bilirubin is a potent endogenous antioxidant and immunomodulating substance, implicated also involved in cell signalization and various metabolic pathways. Mild elevation of its systemic concentrations provides substantial protection against numerous oxidative stress and inflammation-mediated diseases. Rare reports in the literature suggest that serum bilirubin might also be relevant to physical performance. The aim of the current study was to evaluate serum bilirubin concentrations and prevalence of Gilbert syndrome in elite athletes. METHODS: The study was carried out in 536 consecutive healthy elite athletes and in 2,594 individuals of the Czech post-MONICA study randomly selected from the Czech general population. Serum bilirubin concentrations, prevalence of benign hyperbilirubinemia >17 umol/L (1 mg/dL, a phenotypic sign of Gilbert syndrome, GS), and variant of the UGT1A1 promoter gene (rs81753472) were evaluated in study subjects. RESULTS: As compared to Czech general population, significantly higher serum bilirubin concentrations were found in elite athletes (9.6 vs. 11.6 umol/L, p<0.001), and this difference was observed in both men (11.3 vs. 12.6 umol/L, p<0.001) and women (8.3 vs. 10.5 umol/L, p<0.001). In addition, also the prevalence of a phenotypic GS was significantly higher in elite athletes (9.6 vs. 22%, p<0.001). Serum bilirubin concentrations in elite athletes were positively correlated with serum total antioxidant status (p<0.05). CONCLUSION: Elite athletes have significantly higher serum concentrations of serum bilirubin, the most potent endogenous antioxidant substance. Simultaneously, also the prevalence of GS syndrome is much higher in elite athletes, suggesting that mild elevation of serum bilirubin might predispose to better physical performance.

Název v anglickém jazyce

Elite athletes have significantly elevated serum bilirubin concentrations.

Popis výsledku anglicky

INTRODUCTION: Bilirubin is a potent endogenous antioxidant and immunomodulating substance, implicated also involved in cell signalization and various metabolic pathways. Mild elevation of its systemic concentrations provides substantial protection against numerous oxidative stress and inflammation-mediated diseases. Rare reports in the literature suggest that serum bilirubin might also be relevant to physical performance. The aim of the current study was to evaluate serum bilirubin concentrations and prevalence of Gilbert syndrome in elite athletes. METHODS: The study was carried out in 536 consecutive healthy elite athletes and in 2,594 individuals of the Czech post-MONICA study randomly selected from the Czech general population. Serum bilirubin concentrations, prevalence of benign hyperbilirubinemia >17 umol/L (1 mg/dL, a phenotypic sign of Gilbert syndrome, GS), and variant of the UGT1A1 promoter gene (rs81753472) were evaluated in study subjects. RESULTS: As compared to Czech general population, significantly higher serum bilirubin concentrations were found in elite athletes (9.6 vs. 11.6 umol/L, p<0.001), and this difference was observed in both men (11.3 vs. 12.6 umol/L, p<0.001) and women (8.3 vs. 10.5 umol/L, p<0.001). In addition, also the prevalence of a phenotypic GS was significantly higher in elite athletes (9.6 vs. 22%, p<0.001). Serum bilirubin concentrations in elite athletes were positively correlated with serum total antioxidant status (p<0.05). CONCLUSION: Elite athletes have significantly higher serum concentrations of serum bilirubin, the most potent endogenous antioxidant substance. Simultaneously, also the prevalence of GS syndrome is much higher in elite athletes, suggesting that mild elevation of serum bilirubin might predispose to better physical performance.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30401 - Health-related biotechnology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Book of Abstracts of the 27th Annual Congress of the European College of Sport Science 2022.

ISBN

978-3-9818414-5-9

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

656

Název nakladatele

European College of Sport Science

Místo vydání

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Místo konání akce

Sevilla - Španělsko

Datum konání akce

30. 8. 2022

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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