Xanthomas: Clinical and pathophysiological relations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282525" target="_blank" >RIV/00216208:11110/14:10282525 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10282525

Výsledek na webu

<a href="http://biomed.papers.upol.cz/pdfs/bio/2014/02/04.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2014/02/04.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.016" target="_blank" >10.5507/bp.2014.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Xanthomas: Clinical and pathophysiological relations

Popis výsledku v původním jazyce

Background. Xanthomas are well circumscribed lesions in the connective tissue of the skin, tendons or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low density lipoprotein (LDL) particles and their oxidative modification. Results. Until recently, xanthelasma was considered to be only a cosmetic lesion; however, according to the results of recent prospective studies it is connected with an increased cardiovascularrisk and reduced average lifespan. Pathogenetic mechanisms involved in the development of xanthomas resemble early stages of atherogenesis. In clinical practice, xanthomas can signalise various congenital or acquired dyslipidemias. The most prevalent form of xanthomas is xanthelasma palpebrarum. Tendinous and tuberous xanthomas are typical for autosomal dominant hypercholester-olemia, as well as for some rare conditions, such as cerebrotendinous xanthomatosis and familial beta-sitosterol

Název v anglickém jazyce

Xanthomas: Clinical and pathophysiological relations

Popis výsledku anglicky

Background. Xanthomas are well circumscribed lesions in the connective tissue of the skin, tendons or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low density lipoprotein (LDL) particles and their oxidative modification. Results. Until recently, xanthelasma was considered to be only a cosmetic lesion; however, according to the results of recent prospective studies it is connected with an increased cardiovascularrisk and reduced average lifespan. Pathogenetic mechanisms involved in the development of xanthomas resemble early stages of atherogenesis. In clinical practice, xanthomas can signalise various congenital or acquired dyslipidemias. The most prevalent form of xanthomas is xanthelasma palpebrarum. Tendinous and tuberous xanthomas are typical for autosomal dominant hypercholester-olemia, as well as for some rare conditions, such as cerebrotendinous xanthomatosis and familial beta-sitosterol

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

158

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

181-188

Kód UT WoS článku

000338628200004

EID výsledku v databázi Scopus

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