Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282874" target="_blank" >RIV/00216208:11110/14:10282874 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10282874

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jns.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.jns.2014.10.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2014.10.002" target="_blank" >10.1016/j.jns.2014.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment

Popis výsledku v původním jazyce

Background: Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. Objectives: The aim of this study is to determine if change in brain MRI metrics predicts evolution of PASAT in high functioning clinically isolated syndrome (CIS) patients on disease-modifying treatment (DMT). Methods: This prospective 48-month observational study examined 128 CIS patients treated with 30. ?g of intramuscular interferon beta-1a once a week. The correlation between PASAT and MRI measures was assessed at baseline, at 6. months and then annually over the 48-month follow up. Linear mixed model analysis adjusted for age, gender, education and DMT was used to model the temporal association between MRI measures and PASAT performance. Results: MRI revealed 2.5% gray matter (GM) v

Název v anglickém jazyce

Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment

Popis výsledku anglicky

Background: Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. Objectives: The aim of this study is to determine if change in brain MRI metrics predicts evolution of PASAT in high functioning clinically isolated syndrome (CIS) patients on disease-modifying treatment (DMT). Methods: This prospective 48-month observational study examined 128 CIS patients treated with 30. ?g of intramuscular interferon beta-1a once a week. The correlation between PASAT and MRI measures was assessed at baseline, at 6. months and then annually over the 48-month follow up. Linear mixed model analysis adjusted for age, gender, education and DMT was used to model the temporal association between MRI measures and PASAT performance. Results: MRI revealed 2.5% gray matter (GM) v

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Svazek periodika

347

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

229-234

Kód UT WoS článku

000347576500035

EID výsledku v databázi Scopus

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