Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283651" target="_blank" >RIV/00216208:11110/14:10283651 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-642-45198-0_9" target="_blank" >http://dx.doi.org/10.1007/978-3-642-45198-0_9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-642-45198-0_9" target="_blank" >10.1007/978-3-642-45198-0_9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis

Popis výsledku v původním jazyce

Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias.

Název v anglickém jazyce

Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis

Popis výsledku anglicky

Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias.

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Epigenetics and Human Health

ISBN

978-3-642-45197-3

Počet stran výsledku

13

Strana od-do

233-245

Počet stran knihy

416

Název nakladatele

Springer-Verlag Berlin Heidelberg

Místo vydání

Heidelberg

Kód UT WoS kapitoly

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