Heart ventricles specific stress-induced changes in beta-adrenoceptors and muscarinic receptors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283666" target="_blank" >RIV/00216208:11110/14:10283666 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4149/gpb_2014002" target="_blank" >http://dx.doi.org/10.4149/gpb_2014002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2014002" target="_blank" >10.4149/gpb_2014002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Heart ventricles specific stress-induced changes in beta-adrenoceptors and muscarinic receptors

Popis výsledku v původním jazyce

The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three beta-adrenoceptors (beta-AR) in rat rightheart ventricles exposed to acute (1 session) and repeated (7 sessions) immobilization stress (IMMO) vs. previously observed changes in left ventricles. Density of muscarinic receptors as main cardio-inhibitive receptors was also measured. In the rightventricles, noradrenaline and adrenaline were increased. No beta(1)-AR changes were observed, in spite of the increased sympathetic activity. On the other hand, we have found a decrease of beta(2)-AR gene expression (reduction to 30%) after 7 IMMO and protein (to 59%) after 1 IMMO. beta(3)-AR gene expression was increased after 7 IMMO. Muscarinic receptor density was not changed. When comparing correlation in left and right ventricles, there was strong correlation between adrenaline and

Název v anglickém jazyce

Heart ventricles specific stress-induced changes in beta-adrenoceptors and muscarinic receptors

Popis výsledku anglicky

The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three beta-adrenoceptors (beta-AR) in rat rightheart ventricles exposed to acute (1 session) and repeated (7 sessions) immobilization stress (IMMO) vs. previously observed changes in left ventricles. Density of muscarinic receptors as main cardio-inhibitive receptors was also measured. In the rightventricles, noradrenaline and adrenaline were increased. No beta(1)-AR changes were observed, in spite of the increased sympathetic activity. On the other hand, we have found a decrease of beta(2)-AR gene expression (reduction to 30%) after 7 IMMO and protein (to 59%) after 1 IMMO. beta(3)-AR gene expression was increased after 7 IMMO. Muscarinic receptor density was not changed. When comparing correlation in left and right ventricles, there was strong correlation between adrenaline and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

8

Strana od-do

357-364

Kód UT WoS článku

000339306200009

EID výsledku v databázi Scopus

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