Repeated Immobilization Stress Increases Expression of Beta(3)-Adrenoceptor in the Left Ventricle and Atrium of the Rat Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10189804" target="_blank" >RIV/00216208:11110/14:10189804 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/smi.2515" target="_blank" >http://dx.doi.org/10.1002/smi.2515</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/smi.2515" target="_blank" >10.1002/smi.2515</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Repeated Immobilization Stress Increases Expression of Beta(3)-Adrenoceptor in the Left Ventricle and Atrium of the Rat Heart

Popis výsledku v původním jazyce

Stress is a contributor of many cardiovascular diseases. Positive inotropic and chronotropic effects of catecholamines are regulated via Beta-adrenergic receptors (ARs). Many reports exist concerning changes of cardiac Beta1 - and Beta2 -ARs in stress, but only a few deal with modulation of cardiac Beta3 -AR. Our aim was to analyze the expression and binding sites of Beta1 -, Beta2 - and Beta3 -ARs and adenylyl cyclase activity in the left ventricle, and Beta3 -AR expression and binding in the left atrium of rats exposed to acute and chronic immobilization stress (IMO). The concentration of noradrenaline in the ventricle decreased, while adrenaline increased, especially after repeated IMO. The mRNA and protein levels, and binding sites of Beta3 -subtype significantly rose following chronic IMO, while all parameters for Beta2 -AR dropped after single and repeated exposure.

Název v anglickém jazyce

Repeated Immobilization Stress Increases Expression of Beta(3)-Adrenoceptor in the Left Ventricle and Atrium of the Rat Heart

Popis výsledku anglicky

Stress is a contributor of many cardiovascular diseases. Positive inotropic and chronotropic effects of catecholamines are regulated via Beta-adrenergic receptors (ARs). Many reports exist concerning changes of cardiac Beta1 - and Beta2 -ARs in stress, but only a few deal with modulation of cardiac Beta3 -AR. Our aim was to analyze the expression and binding sites of Beta1 -, Beta2 - and Beta3 -ARs and adenylyl cyclase activity in the left ventricle, and Beta3 -AR expression and binding in the left atrium of rats exposed to acute and chronic immobilization stress (IMO). The concentration of noradrenaline in the ventricle decreased, while adrenaline increased, especially after repeated IMO. The mRNA and protein levels, and binding sites of Beta3 -subtype significantly rose following chronic IMO, while all parameters for Beta2 -AR dropped after single and repeated exposure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stress and Health

ISSN

1532-3005

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

301-309

Kód UT WoS článku

000343060600005

EID výsledku v databázi Scopus

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