The effects of hydrocortisone on rat heart muscarinic and adrenergic alpha(1), beta(1) and beta(2) receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030157" target="_blank" >RIV/67985823:_____/03:20030157 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effects of hydrocortisone on rat heart muscarinic and adrenergic alpha(1), beta(1) and beta(2) receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling.

Popis výsledku v původním jazyce

We injected rats with hydrocortisone for 1-12 days and measured the densities of cardiac muscarinic receptors, adrenoceptors and propranolol-resistant biding sites. The density of cardiac muscarinic receptors increased (in both the atria and the ventricles). The density of beta1-adrenoceptors increased in the atria and was little changed in the vetricles. The density of beta2-adrenoceptors increased in both the atria and the ventricles. The number of alpha1-adrenoceptors decreased, and transient increase in the atria and no changes in the ventricles followed it. The density of propranolol-resistant binding sites first increased and then diminished in the atria and did not change in the ventricles. In can indicate that changes in receptor densities could be one from the mechanisms that participate in maitaining stable functional output.

Název v anglickém jazyce

The effects of hydrocortisone on rat heart muscarinic and adrenergic alpha(1), beta(1) and beta(2) receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling.

Popis výsledku anglicky

We injected rats with hydrocortisone for 1-12 days and measured the densities of cardiac muscarinic receptors, adrenoceptors and propranolol-resistant biding sites. The density of cardiac muscarinic receptors increased (in both the atria and the ventricles). The density of beta1-adrenoceptors increased in the atria and was little changed in the vetricles. The density of beta2-adrenoceptors increased in both the atria and the ventricles. The number of alpha1-adrenoceptors decreased, and transient increase in the atria and no changes in the ventricles followed it. The density of propranolol-resistant binding sites first increased and then diminished in the atria and did not change in the ventricles. In can indicate that changes in receptor densities could be one from the mechanisms that participate in maitaining stable functional output.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Naunyn-Schmiedebergs Archives of Pharmacology

ISSN

0028-1298

e-ISSN

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Svazek periodika

368

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

366-376

Kód UT WoS článku

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EID výsledku v databázi Scopus

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